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In immunology, clonal selection theory explains the functions of cells of the immune system (lymphocytes) in response to specific antigens invading the body. The concept was introduced by Australian doctor Frank Macfarlane Burnet in 1957, in an attempt to explain the great diversity of antibodies formed during initiation of the immune response .
The clonal selection theory became one of the central concepts of immunology, and Burnet regarded his contributions to the theoretical understanding of the immune system as his greatest contribution to science, [108] writing that he and Jerne should have received the Nobel for this work. [109]
Clonal Selection Pseudo code on AISWeb; CLONALG in Matlab developed by Leandro de Castro and Fernando Von Zuben; Optimization Algorithm Toolkit in Java developed by Jason Brownlee which includes the following clonal selection algorithms: Adaptive Clonal Selection (ACS), Optimization Immune Algorithm (opt-IMMALG), Optimization Immune Algorithm (opt-IA), Clonal Selection Algorithm (CLONALG ...
David Talmage (1919-2014), clonal selection theory; James S. Tan (1927-2006) Reyes Tamez (1952-) Kevin J. Tracey (1957-) Jan Vilcek (1933-) Ellen Vitetta; Alexander S. Wiener (1907-1976) Don Wiley (1944-2001), crystallography of HLA proteins; Ian Wilson (biologist) Ernst Witebsky (1901-1969), isolation and partial characterization of A and B ...
He made significant contributions to the clonal selection theory. [2] Career ... Journal of Immunology. 153 (3): 919 ...
Myriad receptors are produced through a process known as clonal selection. [ 2 ] [ 3 ] According to the clonal selection theory, at birth, an animal randomly generates a vast diversity of lymphocytes (each bearing a unique antigen receptor) from information encoded in a small family of genes.
In the late 1950s however, the works of three scientists—Jerne, Talmage and Burnet (who largely modified the theory)—gave rise to the clonal selection theory, which proved all the elements of Ehrlich's hypothesis except that the specific receptors that could neutralize the agent were soluble and not membrane-bound. [17] [30]
This process – called "clonal expansion" – allows the body to quickly mobilise an army of clones, as and when required. Such immune response is anticipatory and its specificity is assured by pre-existing clones of lymphocytes, which expand in response to specific antigen (process called "clonal selection").