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A systematic review and meta-analysis in 2012 [16] concluded that there is insufficient evidence to establish a difference between metformin and clomiphene citrate in terms of ovulation, pregnancy, live birth, miscarriage, and multiple pregnancy rates in women with PCOS and a BMI less than 32 kg/m 2. [16]
Early trials in women with PCOS found that metformin helped give a small benefit in insulin sensitivity, reduced weight and helped restore periods, Dr. Ohri says. Because of this, metformin is ...
In PCOS, in addition to improved glucose markers, metformin can help to restore regular menstrual cycles, help with fertility, as well as improve acne, Dr. Wheeler notes.
Can Help Prevent PCOS and Manage Anovulatory Infertility. ... A study on 702 women found that the clinical pregnancy rate for those using metformin versus a placebo group was significantly increased.
In those with polycystic ovarian syndrome (PCOS), tentative evidence shows that metformin use increases the rate of live births. [50] This includes in those who have not been able to get pregnant with clomiphene. [51] Metformin does not appear to change the risk of miscarriage. [50]
Advanced maternal age causes decreased success rates in ovarian hyperstimulation. In ovarian hyperstimulation combined with IUI, women aged 38–39 years appear to have reasonable success during the first two cycles, with an overall live birth rate of 6.1% per cycle. [12]