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The eyes begin to develop as a pair of diverticula (pouches) from the lateral aspects of the forebrain.These diverticula make their appearance before the closure of the anterior end of the neural tube; [1] [2] after the closure of the tube around the 4th week of development, they are known as the optic vesicles.
The surface ectoderm, AKA external ectoderm, is one of the two early embryonic divisions of the ectoderm. The other early division of the ectoderm is the neuroectoderm. The surface ectoderm develops into the following structures: Skin (only the epidermis; the dermis is derived from the mesoderm) (along with glands, hair, and nails)
Bone morphogenic proteins are known to stimulate eye lens formation. During early development of eyes, the formation of the optic vesicle is essential in Mice and BMP4 expressed strongly in the optic vesicle and weakly in the surrounding mesenchyme and surface ectoderm. This concentration gradient of BMP4 in optic vesicle is critical for lens ...
The lens and the epithelium of the cornea arise from the surface ectoderm directly; other structures come from either the neural ectoderm or the neural crest, which itself arises from the ectoderm. The mesoderm has limited contributions: it is the origin of the vitreous body , the blood vessels of the eye, and the extraocular muscles.
Long-term contact lens use can lead to alterations in corneal thickness, stromal thickness, curvature, corneal sensitivity, cell density, and epithelial oxygen uptake. . Other structural changes may include the formation of epithelial vacuoles and microcysts (containing cellular debris), corneal neovascularization, as well as the emergence of polymegethism in the corneal endoth
Surface ectoderm forms the lens, corneal epithelium and eyelid. The extracellular mesenchyme forms the sclera , the corneal endothelium and stroma , blood vessels , muscles , and vitreous . The eye begins to develop as a pair of optic vesicles on each side of the forebrain at the end of the fourth week of pregnancy.
More specifically, it is needed for the surface ectoderm to fully develop. Pax6 has been identified as a necessary transcription factor for the thickness of the lens placode. [3] SOX2 is a transcription factor that works alongside Pax6 to develop the lens placode. They maintain the same protein levels in the ectoderm.
Figure 1.0 - Basic anatomical features of the human eye. Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to combat a multitude of diseased states of the eye. These states may include bacterial infections, eye injury, glaucoma, and dry eye. [1]