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Vitamin B 12 was discovered as a result of pernicious anemia, an autoimmune disorder in which the blood has a lower than normal number of red blood cells, due to a deficiency of vitamin B 12. [5] [16] The ability to absorb the vitamin declines with age, especially in people over 60. [17]
Sulbutiamine sold under the brand names Arcalion, Enerion, and Sulbuxin is a synthetic derivative of thiamine (vitamin B 1). In France, it is used to treat symptoms of weakness or fatigue . In Uruguay , it is prescribed when there is thiamine deficiency, mainly in patients with asthenia , overwork, apathy , depressive states, memory disorders ...
The RDA for pregnancy is 1.4 mg/day, for lactation is 1.5 mg/day. For children ages 1–17 years the RDA increases with age from 0.5 to 1.5 mg/day. The adult UL was set at 40–45 mg/day for women and 50–60 mg/day for men, with the lower values in those ranges for adults over 70 years of age. [25]
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