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As of July 2024, ALTO-100 is in phase 2 clinical trials for MDD, bipolar depression, and PTSD. [4] A phase 3 trial for MDD is being planned. [4] Findings of the effectiveness of ALTO-100 in treating MDD in phase 1 and 2 trials have been mixed, although cognitive and memory improvements have been observed.
The CDR system (The CDR system) is a computerized battery of cognitive tests designed in the late 1970s by Professor Keith Wesnes at the University of Reading in Berkshire, England, for repeated testing in clinical trials. Task stimuli are presented in a laptop computer and participants respond via 'YES' and 'NO' buttons on a two-button ...
LATE is a term that describes a prevalent medical condition with impaired memory and thinking in advanced age, often culminating in the dementia clinical syndrome. [1] In other words, the symptoms of LATE are similar to those of Alzheimer's disease. The acronym LATE stands for Limbic-predominant Age-related TDP-43 Encephalopathy.
Naismith's research focus on aging, dementia, and cognitive decline, particularly modifiable risk factors such as sleep disturbance, is a key part of her career. [1] [6] One project, the REducing Sleep Apnoea for the PrEvention of Dementia (REShAPED) trial, received funding from the National Health and Medical Research Council (NHMRC).
From a clinical perspective, a view of five distinct types of memory, is in most cases sufficient. [3] Semantic memory and episodic memory (collectively called declarative memory or explicit memory); procedural memory and priming or perceptual learning (collectively called non-declarative memory or implicit memory) all four of which are long ...
The difference in memory between normal aging and a memory disorder is the amount of beta-amyloid deposits, hippocampal neurofibrillary tangles, or amyloid plaques in the cortex. If there is an increased amount, memory connections become blocked, memory functions decrease much more than what is normal for that age and a memory disorder is ...
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