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Cytokine is a monthly peer-reviewed academic journal covering the study of cytokines as they relate to multiple disciplines, including molecular biology, immunology, and genetics. It was established in 1989 and is published by Elsevier .
An inflammatory cytokine is a type of cytokine (a signaling molecule) that is secreted from immune cells and certain other cell types that promotes inflammation. Inflammatory cytokines are predominantly produced by T helper cells ( T h ) and macrophages and involved in the upregulation of inflammatory reactions. [ 1 ]
Cytokines are important in health and disease, specifically in host immune responses to infection, inflammation, trauma, sepsis, cancer, and reproduction. The word comes from the ancient Greek language : cyto , from Greek κύτος, kytos , 'cavity, cell' + kines , from Greek κίνησις, kinēsis , 'movement'.
Cancer immunology (immuno-oncology) is an interdisciplinary branch of biology and a sub-discipline of immunology that is concerned with understanding the role of the immune system in the progression and development of cancer; the most well known application is cancer immunotherapy, which utilises the immune system as a treatment for cancer.
Cellular immunity protects the body through: T-cell mediated immunity or T-cell immunity: activating antigen-specific cytotoxic T cells that are able to induce apoptosis in body cells displaying epitopes of foreign antigen on their surface, such as virus-infected cells, cells with intracellular bacteria, and cancer cells displaying tumor antigens;
According to the Journal Citation Reports, the journal has a 2020 impact factor of 6.968. [ 1 ] Immunology includes the use of certain components of the immune system ( antibodies, cells & cytokines), etc. for the treatment of various cancers and autoimmune diseases and the manipulation of immune system through vaccines for the prevention and ...
Cytokine-induced killer cells (CIK) cells are a group of immune effector cells featuring a mixed T- and natural killer (NK) cell-like phenotype.They are generated by ex vivo incubation of human peripheral blood mononuclear cells (PBMC) or cord blood mononuclear cells with interferon-gamma (), anti-CD3 antibody, recombinant human interleukin (IL)-1 and recombinant human interleukin (IL)-2.
Lymphotoxin alpha, a member of the tumor necrosis factor superfamily, is a cytokine produced by lymphocytes. LT-α 1-β 2 can interact with receptors such as LT-β receptors. [12] Absence of LT-β on cell surfaces will diminish the ability of LT-α to form LT-α 1-β 2, thus decreasing its effective ability as a cytokine.