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The study concluded that sublingually administered misoprostol dosed at 600 μg or 400 μg had greater instances of fever and diarrhea due to its quicker onset of action, higher peak concentration and bioavailability in comparison to vaginal or oral misoprostol. [42] For the indication of medical abortion, bleeding and cramping is commonly ...
Misoprostol causes uterine contractions, forcing the body to expel the pregnancy. It can be used alone, but it is more effective in conjunction with mifepristone. Misoprostol is swallowed, placed inside the vagina, or dissolved in the mouth for this purpose. [18] Misoprostol can also be used to induce abortion.
Vaginally administered misoprostol had improved outcomes of inducing labor within twenty four hours compared to oxytocin, but was associated with uterine hyperstimulation. [15] Misoprostol is an agonist of EP1 and EP3 receptors, and can cause a greater stimulation at lower concentrations.
The success rate of misoprostol alone for terminating pregnancy (93%) is nearly the same as the mifepristone-misoprostol combination (96%). However, 15% of the women using misoprostol alone required a surgical follow-up procedure, which is significantly more than the mifepristone-misoprostol combination.
Mifepristone, and also known by its developmental code name RU-486, is a drug typically used in combination with misoprostol to bring about a medical abortion during pregnancy. [8] This combination is 97% effective [ 9 ] during the first 63 days (9 weeks) of pregnancy , yet effective in the second trimester as well.
While misoprostol is 80 to 100% effective at terminating a pregnancy on its own, according to the Kaiser Family Foundation, taking both medications is more effective and has fewer side effects.
Intravaginal, endocervical or extra-amniotic administration of prostaglandin, such as dinoprostone or misoprostol. [7] Prostaglandin E2 is the most studied compound and with most evidence behind it. [citation needed] A range of different dosage forms are available with a variety of routes possible. The use of misoprostol has been extensively ...
Three doctors told NBC News that if she was given misoprostol, depending on the dose, it could have played a role. One of its most dangerous side effects is to potentially reduce a baby’s blood ...