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  2. Nucleotide excision repair - Wikipedia

    en.wikipedia.org/wiki/Nucleotide_excision_repair

    Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts — these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA segment that contains ...

  3. DNA repair - Wikipedia

    en.wikipedia.org/wiki/DNA_repair

    DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. [1] In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. [2]

  4. ERCC1 - Wikipedia

    en.wikipedia.org/wiki/ERCC1

    ERCC1. DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene. [5] Together with ERCC4, ERCC1 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination. [6][7] Many aspects of these two gene products are described together here because they are partners during DNA repair.

  5. Base excision repair - Wikipedia

    en.wikipedia.org/wiki/Base_excision_repair

    Base excision repair (BER) is a cellular mechanism, studied in the fields of biochemistry and genetics, that repairs damaged DNA throughout the cell cycle. It is responsible primarily for removing small, non-helix-distorting base lesions from the genome. The related nucleotide excision repair pathway repairs bulky helix-distorting lesions.

  6. Excinuclease - Wikipedia

    en.wikipedia.org/wiki/Excinuclease

    Excinuclease. Excision endonuclease, also known as excinuclease or UV-specific endonuclease, is a nuclease (enzyme) which excises a fragment of nucleotides during DNA repair. The excinuclease cuts out a fragment by hydrolyzing two phosphodiester bonds, one on either side of the lesion in the DNA. This process is part of "nucleotide excision ...

  7. SOS response - Wikipedia

    en.wikipedia.org/wiki/SOS_response

    The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis are induced. The system involves the RecA protein (Rad51 in eukaryotes). The RecA protein, stimulated by single-stranded DNA, is involved in the inactivation of the repressor (LexA) of SOS response genes thereby inducing the ...

  8. AP endonuclease - Wikipedia

    en.wikipedia.org/wiki/AP_endonuclease

    PDB = 1de9. [1] Apurinic/apyrimidinic (AP) endonuclease is an enzyme that is involved in the DNA base excision repair pathway (BER). Its main role in the repair of damaged or mismatched nucleotides in DNA is to create a nick in the phosphodiester backbone of the AP site created when DNA glycosylase removes the damaged base.

  9. Richard Wood (molecular biologist) - Wikipedia

    en.wikipedia.org/wiki/Richard_Wood_(molecular...

    Richard D. Wood (born June 3, 1955 in Boulder, Colorado) is an American molecular biologist specializing in research on DNA repair and mutation. [7] He is known for pioneering studies on nucleotide excision repair (NER), particularly for reconstituting the minimum set of proteins involved in this process, [8] [9] identifying proliferating cell nuclear antigen [10] as part of the NER complex ...