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Midodrine is a prodrug which forms the active metabolite, desglymidodrine, which is an α 1-adrenergic receptor agonist and exerts its actions via activation of α 1-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure.
The drug has been shown to enhance working memory capacities in normal aging adults. [ 4 ] In age-related memory impairment, it has a positive effect on psychophysiological state of elderly people, improving memory and attention and increasing the velocity of psychomotor reactions and lability of nervous processes.
Scientists have been looking inside of the human brain for quite some time now, striving to understand brain diseases and look for cures, but sometimes huge discoveries are found in unlikely places.
Pemoline has been used in the treatment of ADHD and narcolepsy. [2] [1] [5] It has also been used in the treatment of excessive daytime sleepiness. [8]The medication was typically used at doses of 18.75 to 112.5 mg once per day in the treatment of ADHD, with the effective dose for most people being in the range of 56.25 to 75 mg. [1] [2] The onset of action of pemoline is gradual and ...
Trodusquemine is an aminosterol (polyamine steroid conjugate) that inhibits protein tyrosine phosphatase 1B (PTP1B) activity. [1] The compound exhibits broad-spectrum antimicrobial activity [2] and numerous regenerative, neuroprotective, anti-atherosclerotic, antitumor, antiangiogenic, antiobesity, and anxiolytic properties. [3]
In humans, tolerance to the anticonvulsant effects of clobazam may occur [27] and withdrawal seizures may occur during abrupt or over-rapid withdrawal. [28] Clobazam as with other benzodiazepine drugs can lead to physical dependence, addiction, and what is known as the benzodiazepine withdrawal syndrome.
Side effects associated with dienogest are the same as those expected of a progestogen. [7] They include menstrual irregularities, headaches, nausea, breast tenderness, depression, acne, weight gain, flatulence, and others. [14] Dienogest produces no androgenic side effects and has little effect on metabolic and lipid hemostatic parameters. [34]
After single oral administration of 100 mg the maximum plasma concentration is reached after 3 hours and amounts to 33.2 ng/mL. [3] Therapeutic concentrations of opipramol range from 140 to 550 nmol/L. [26] The plasma protein binding amounts to approximately 91% and the volume of distribution is approximately 10 L/kg. [3]