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Recombinant feline interferon omega (RFeIFN-ω), sold under the brand name Virbagen Omega among others, is a recombinant version of a cat interferon alpha. [1] It is used to treat a range of viral diseases in cats and dogs, including canine parvovirus, feline leukemia virus (FeLV), and feline immunodeficiency virus (FIV) in many countries.
With the advent of Direct-Acting-Antivirals (DAAs — ), interferon-based treatment regimens gradually fell out of fashion due to relatively poor efficacy and high frequency of adverse side-effects. [ 4 ] [ 7 ] [ 11 ] No longer recommended, the use of PEGylated interferon alfa-2b has essentially ceased in all countries, where DAA therapeutics ...
Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and produced recombinantly in E. coli [1] in the laboratory of Charles Weissmann at the University of Zurich, in 1980.
Pegylated interferon (PEG-IFN) is a class of medication that includes three different drugs as of 2012: [1] Pegylated interferon-alpha-2a; Pegylated interferon-alpha-2b; Pegylated interferon beta-1a [2] In these formulations, Polyethylene glycol (PEG) is added to make interferon last longer in the body. [3]
The RESPOND-2 trial [11] studied patients with chronic hepatitis C genotype 1 who did not have a sustained response to therapy with peginterferon-ribavirin therapy. All patients received a month of peginterferon alfa-2b and ribavirin before being randomized to one of three arms. The first arm received placebo plus peginterferon-ribavirin for 44 ...
Peginterferon beta-1a, sold under the brand name Plegridy, is medication used to treat multiple sclerosis. [ 4 ] [ 5 ] The most common side effects include headache, muscle pain, joint pain, influenza (flu)-like symptoms, pyrexia (fever), chills, asthenia (weakness), and erythema (reddening of the skin), pain or pruritus (itching) at the ...