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sunitinib (Sutent) is labeled for treatment of progressive, well-differentiated pancreatic neuroendocrine tumors in patients with unresectable locally advanced or metastatic disease. [ 27 ] [ 28 ] Sutent also has approval from the European Commission for the treatment of 'unresectable or metastatic, well-differentiated pancreatic neuroendocrine ...
Pancreatic neuroendocrine tumors (PanNETs) are often referred to as "islet cell tumors", [54] [55] or "pancreatic endocrine tumors" [4] The PanNET denomination is in line with current WHO guidelines.
[1] [11] [12] [13] When it comes to comparing these two PRRT, Y-labeled and Lu-labeled PRRTs, it appears that Y-labeled is more effective for larger tumors, while Lu-labeled is better for smaller and primary tumors. The lack of ɤ-emission with Y-labeled PPRTs is also an important difference between Lu peptides and Y peptide.
177 Lu dotatate was approved in the United States for the treatment of SSTR positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including foregut, midgut and hindgut neuroendocrine tumors in adults, in January 2018. [3] [6] [7] This was the first time a radiopharmaceutical had been approved for the treatment of GEP-NETs in the ...
The tumor typically produces serotonin, Tachykinin peptides and other substances, which cause flushing, tachycardia, diarrhea and in some cases fibrosis of the heart valves. [citation needed] There are often several small and highly fibrotic tumors present in the intestine. The tumors often spread to the mesenteries and the liver. [citation needed]
The small minority of tumors that arise elsewhere in the pancreas are mainly pancreatic neuroendocrine tumors (PanNETs). [30] Neuroendocrine tumors (NETs) are a diverse group of benign or malignant tumors that arise from the body's neuroendocrine cells, which are responsible for integrating the nervous and endocrine systems.
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