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Invasive apocrine carcinomas of the breast with an appreciable amount of apocrine gland-like tissue was termed apocrine breast tumors for decades when in 1988 d'Amore et al named a subset of these carcinomas in which >90% of its tissue consisted of apocrine gland-like tissue as pure invasive apocrine carcinoma. [6]
Apocrine ductal carcinoma in situ (ACDIS) is a very rare breast carcinoma which is regarded as a variant of the ductal carcinoma in situ breast tumors. ACDIS tumors have microscopic histopathology features that are similar to pure apocrine carcinoma of the breast tumors but differ from them in that they are completely localized, i.e. have not invaded nearby tissues or metastasized to distant ...
Apocrine gland carcinoma is a cutaneous condition characterized by skin lesions which form in the axilla or anogenital regions. [1]: 670 ...
Extramammary Paget's disease (EMPD) is a rare and slow-growing cancer, which occurs within the epithelial tissues [1] and accounts for 6.5% of all Paget's disease. [2] This disease presents similarly to the more conventional form of mammary Paget's disease (MPD). [3]
The phenotypes expressed by the genotypes include cerumen type (wet or dry ear wax), osmidrosis (odor associated with sweat caused by excessive apocrine secretion), and possibly breast cancer risk, although there is ongoing debate on whether there is a real correlation of the wet ear wax phenotype to breast cancer susceptibility.
Syringocystadenoma papilliferum is a rare non-malignant adnexal neoplasm that develops from apocrine or eccrine sweat glands and can be identified histologically by cystic, papillary, and ductal invaginations into the dermis lined by double-layered outer cuboidal and luminal high columnar epithelium and connected to the epidermis.
Micrograph showing apocrine-type metaplasia of the breast with typical oncocytes. [2] H&E stain. Oncocytes (left of image), as seen in a renal oncocytoma. H&E stain. An oncocyte is an epithelial cell characterized by an excessive number of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. Oncocytes can be benign or malignant.
With the specific characteristics, the MDA-MB-453 cell cancer line is now classified as a Triple Negative Breast Cancer cell line model. [1] One study suggests that the MDA-MB-453 cell line is not the best model for an apocrine breast cancer model. During the experiment, there was a mutation in the K-RAS gene that was not previously identified ...