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  2. Hepatotoxicity - Wikipedia

    en.wikipedia.org/wiki/Hepatotoxicity

    Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.

  3. Hy's law - Wikipedia

    en.wikipedia.org/wiki/Hy's_law

    Hy's law is a rule of thumb that a patient is at high risk of a fatal drug-induced liver injury if given a medication that causes hepatocellular injury (not Hepatobiliary injury) with jaundice. [1] The law is based on observations by Hy Zimmerman, a major scholar of drug-induced liver injury.

  4. NAPQI - Wikipedia

    en.wikipedia.org/wiki/NAPQI

    NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen). [1] It is normally produced only in small amounts, and then almost immediately detoxified in the liver.

  5. FDA approves first drug for common form of liver inflammation

    www.aol.com/fda-approves-first-drug-common...

    The US Food and Drug Administration has approved the first medication for a common form of liver inflammation called nonalcoholic steatohepatitis, or NASH, the agency said Thursday.

  6. List of withdrawn drugs - Wikipedia

    en.wikipedia.org/wiki/List_of_withdrawn_drugs

    Dermatologic toxicity. [3] Brotizolam: 1989 UK Animal carcinogenicity. [3] Bromfenac: 1998 US Severe hepatitis and liver failure (requiring transplantation). [2] Bucetin: 1986 Germany Kidney damage [3] Buformin: 1978 Germany Metabolic toxicity. [3] Bunamiodyl: 1963 Canada, UK, US Nephropathy. [11] Butamben (Efocaine)(Butoforme) 1964 US

  7. Naltrexone - Wikipedia

    en.wikipedia.org/wiki/Naltrexone

    Naltrexone is the generic name of the drug and its INN Tooltip International Nonproprietary Name, USAN Tooltip United States Adopted Name, BAN Tooltip British Approved Name, DCF Tooltip Dénomination Commune Française, and DCIT Tooltip Denominazione Comune Italiana, while naltrexone hydrochloride is its USP Tooltip United States Pharmacopeia ...