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Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
H 2-antihistamines bind to histamine H 2 receptors in the upper gastrointestinal tract, primarily in the stomach. Antihistamines that target the histamine H 2-receptor are used to treat gastric acid conditions (e.g., peptic ulcers and acid reflux). Other antihistamines also target H 3 receptors and H 4 receptors.
Nizatidine is a histamine H 2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. [2] It was patented in 1980 and approved for medical use in 1988. [3] [4] It was developed by Eli Lilly.
Most of these symptoms are managed with anti-reflux medications like proton pump inhibitors or antihistamine receptor medications.” ... Dietary changes can help with acid reflux symptoms.
Treatments for acid reflux. Home remedies for acid reflux often involve a mix of lifestyle changes, dietary adjustments, and, in some cases, medication. Here are some common treatment methods:
H1 antagonists, commonly known as antihistamines, are used to alleviate symptoms of allergies and allergic reactions. [ 3 ] H 2 receptor H2 Receptors: Found mainly in the stomach lining (parietal cells), H2 receptors regulate gastric acid secretion by stimulating the production of hydrochloric acid.
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