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Notch-mediated juxtacrine signal between adjacent cells Notch signaling steps. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. [1] Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. [2] The notch receptor is a single-pass transmembrane receptor protein.
Notch-mediated juxtacrine signal between adjacent cells. In biology, juxtracrine signalling (or contact-dependent signalling) is a type of cell–cell or cell–extracellular matrix signalling in multicellular organisms that requires close contact. In this type of signalling, a ligand on one surface binds to a receptor on another adjacent surface.
Charpy test sample with a notch. In mechanical engineering and materials science, a notch refers to a V-shaped, U-shaped, or semi-circular defect deliberately introduced into a planar material. In structural components, a notch causes a stress concentration which can result in the initiation and growth of fatigue cracks.
In the case of Notch-mediated signaling, the signal transduction mechanism can be relatively simple. As shown in Figure 2, the activation of Notch can cause the Notch protein to be altered by a protease. Part of the Notch protein is released from the cell surface membrane and takes part in gene regulation. Cell signaling research involves ...
Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells.
In solid mechanics, a stress concentration (also called a stress raiser or a stress riser or notch sensitivity) is a location in an object where the stress is significantly greater than the surrounding region. Stress concentrations occur when there are irregularities in the geometry or material of a structural component that cause an ...
Example of a set of 53 edged-notched cards used by Gordon Bell to gather information for a book (Computer History Museum) Example of a blank pre-printed edge-notched card designed to store bird population research data (Smithsonian) Example of a commercially-produced notched card reference database, the Isotope Datadex (1961-1970)
A notch filter is a band-stop filter with a narrow stopband ... has a respectable place which it is essential for microwave transceivers. For example, ...