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Cyclobenzaprine was approved for medical use in the United States in 1977. [5] It is available by prescription as a generic medication. [5] In 2022, it was the 45th most commonly prescribed medication in the United States, with more than 13 million prescriptions. [8] [9] It was not available in the United Kingdom as of 2012. [10]
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
Amitriptyline, sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches. [12]
Fibromyalgia is a medical syndrome that causes chronic widespread pain, accompanied by fatigue, awakening unrefreshed, and cognitive symptoms. Other symptoms can include headaches, lower abdominal pain or cramps, and depression. [9] People with fibromyalgia can also experience insomnia [10] and general hypersensitivity.
Antidepressants are a class of medications used very commonly to treat depression. In fact, nearly 13 percent of people 12 and over in the U.S. used antidepressants in 2017, according to the ...
Antidepressant withdrawal syndrome may occur if stopped. [10] There are concerns that use during the later part of pregnancy can harm the developing fetus. [10] Duloxetine was approved for medical use in the United States [10] [13] and the European Union in 2004. [5] [7] It is available as a generic medication. [12]
Antidepressants that have dual mechanisms of action inhibit the reuptake of both serotonin and norepinephrine and, in some cases, inhibit with weak effect the reuptake of dopamine. [10] Antidepressants affect variable neuronal receptors such as muscarinic cholinergic, α 1 - and α 2-adrenergic, H 1-histaminergic, and sodium channels in the ...
MAOIs are an older class of antidepressants, primarily used in the 20th century. Because of their side effects and interaction risk, most MAOIs have been replaced by newer antidepressants over the ...