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2. Hemoglobinuria - Wikipedia

   en.wikipedia.org/wiki/Hemoglobinuria

   Hemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine. [1] The condition is caused by excessive intravascular hemolysis , in which large numbers of red blood cells (RBCs) are destroyed, thereby releasing free hemoglobin into the plasma . [ 2 ]

3. Paroxysmal nocturnal hemoglobinuria - Wikipedia

   en.wikipedia.org/wiki/Paroxysmal_nocturnal...

   Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells. The most common side effects include fever, headache, increased levels of liver enzymes (a sign ...

4. Paroxysmal cold hemoglobinuria - Wikipedia

   en.wikipedia.org/wiki/Paroxysmal_cold_hemoglobinuria

   Paroxysmal cold hemoglobinuria (PCH) or Donath–Landsteiner hemolytic anemia (DLHA) is an autoimmune hemolytic anemia featured by complement-mediated intravascular hemolysis after cold exposure. [1] It can present as an acute non-recurrent postinfectious event in children, or chronic relapsing episodes in adults with hematological malignancies ...

5. Paroxysmal hemoglobinuria - Wikipedia

   en.wikipedia.org/wiki/Paroxysmal_hemoglobinuria

   Paroxysmal hemoglobinuria can refer to: Paroxysmal nocturnal hemoglobinuria; Paroxysmal cold hemoglobinuria; See also. Hemoglobinuria This page was last edited on 29 ...

6. Mechanical hemolytic anemia - Wikipedia

   en.wikipedia.org/wiki/Mechanical_hemolytic_anemia

   This may result in hemoglobinuria. The damage is induced through repetitive mechanical motions such as prolonged marching (march hemoglobinuria) and marathon running. [2] [3] Mechanical damage can also be induced through the chronic condition microangiopathic hemolytic anemia or due to prosthetic heart valves. [1]

7. Intravascular hemolysis - Wikipedia

   en.wikipedia.org/wiki/Intravascular_hemolysis

   Long-term hemoglobinuria is associated with substantial deposition of hemosiderin in proximal tubule (excessive accumulation of hemosiderin in proximal tubule), Fanconi syndrome (damaged renal re-absorption capability of small molecules which give rises to hyper-aminoaciduria, glycosuria, hyperphosphaturia, and bicarbonate and dehydration), and ...