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End organ damage is severe impairment of major body organs due to systemic disease. Commonly this is referred to in diabetes , high blood pressure , or states of low blood pressure or low blood volume. [ 1 ]
Acute end-organ damage may occur, affecting the neurological, cardiovascular, kidney, or other organ systems. Some examples of neurological damage include hypertensive encephalopathy , cerebral vascular accident / cerebral infarction , subarachnoid hemorrhage, and intracranial bleeding .
Neuromuscular junction (motor end-organ) Lamellar corpuscle (Pacinian corpuscle end-organ) The ultimately affected organ in a chain of events, such as a disease process (pathophysiology) or a drug's mechanism of action (sometimes called a target organ in this sense) End organ damage, disease of such organs Ambulatory blood pressure § Target ...
Septic shock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defines septic shock as a subset of sepsis ...
At present, there is no drug or device that can reverse organ failure that has been judged by the health care team to be medically and/or surgically irreversible (organ function can recover, at least to a degree, in patients whose organs are very dysfunctional, where the patient has not died; [citation needed] and some organs, like the liver or ...
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All of these are either a direct result of an end-organ like the heart or the brain not getting enough perfusion—so think chest pain and dizziness. Or from the sympathetic response from the body to help the heart work harder and preserve blood pressure—so think sweating and clammy skin.
An abrupt stop of pulmonary gas exchange lasting for more than five minutes may permanently damage vital organs, especially the brain. Lack of oxygen to the brain causes loss of consciousness. Brain injury is likely if respiratory arrest goes untreated for more than three minutes, and death is almost certain if more than five minutes.