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Endomicroscopy is a technique for obtaining histology-like images from inside the human body in real-time, [1] [2] [3] a process known as ‘optical biopsy’. [4] [5] It generally refers to fluorescence confocal microscopy, although multi-photon microscopy and optical coherence tomography have also been adapted for endoscopic use.
Fluorescence and confocal microscopes operating principle. Confocal microscopy, most frequently confocal laser scanning microscopy (CLSM) or laser scanning confocal microscopy (LSCM), is an optical imaging technique for increasing optical resolution and contrast of a micrograph by means of using a spatial pinhole to block out-of-focus light in image formation. [1]
First workshop of Carl Zeiss in the center of Jena, c. 1847 Carl Zeiss Jena (1910) One of the Stasi's cameras with the special SO-3.5.1 (5/17mm) lens developed by Carl Zeiss, a so-called "needle eye lens", for shooting through keyholes or holes down to 1 mm in diameter 2 historical lenses of Carl Zeiss, Nr. 145077 and Nr. 145078, Tessar 1:4,5 F=5,5cm DRP 142294 (produced before 1910) Carl ...
1846: Carl Zeiss founded Carl Zeiss AG, to mass-produce microscopes and other optical instruments. 1850s: John Leonard Riddell, Professor of Chemistry at Tulane University, invents the first practical binocular microscope. [13] 1863: Henry Clifton Sorby develops a metallurgical microscope to observe structure of meteorites.
Leica Microsystems GmbH is a German microscope manufacturing company. It is a manufacturer of optical microscopes, equipment for the preparation of microscopic specimens and related products. There are ten plants in eight countries with distribution partners in over 100 countries.
The first optically feasible stereomicroscope was invented in 1892 and became commercially available in 1896, produced by Zeiss AG in Jena, Germany. [2] 1896 Greenough Stereo Microscope by Carl Zeiss Jena. American zoologist Horatio Saltonstall Greenough grew up in the elite of Boston, Massachusetts, the son of the famous sculptor Horatio ...