Search results
Results From The WOW.Com Content Network
MT-ND2 is located in mitochondrial DNA from base pair 4,470 to 5,511. [5] The MT-ND2 gene produces a 39 kDa protein composed of 347 amino acids. [10] [11] MT-ND2 is one of seven mitochondrial genes encoding subunits of the enzyme NADH dehydrogenase (ubiquinone), together with MT-ND1, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, and MT-ND6.
The NDUFA12 gene is located on the q arm of chromosome 12 in position 22 and spans 32,386 base pairs. [7] The gene produces a 17 kDa protein composed of 145 amino acids. [10] [11] NDUFA12 is a subunit of the enzyme NADH dehydrogenase (ubiquinone), the largest of the respiratory complexes.
NADH + H + + acceptor ⇌ NAD + + reduced acceptor. NADH dehydrogenase is a flavoprotein that contains iron-sulfur centers. NADH dehydrogenase is used in the electron transport chain for generation of ATP. The EC term NADH dehydrogenase (quinone) (EC 1.6.5.11) is defined for NADH dehydrogenases that use a quinone (excluding ubiquinone) as the ...
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (NDUFS2) also known as NADH-ubiquinone oxidoreductase 49 kDa subunit is an enzyme that in humans is encoded by the NDUFS2 gene. [ 5 ] [ 6 ] The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase ( complex I ).
Three of the conserved, membrane-bound subunits in NADH dehydrogenase are related to each other, and to Mrp sodium-proton antiporters. Structural analysis of two prokaryotic complexes I revealed that the three subunits each contain fourteen transmembrane helices that overlay in structural alignments: the translocation of three protons may be ...
The NDUFA2 gene is located on the long (q) arm of chromosome 5 at position 31.2 and it spans 2,422 base pairs. [6] The NDUFA2 gene produces an 11 kDa protein composed of 99 amino acids. [8] [9] NDUFA2 is a subunit of the enzyme NADH dehydrogenase (ubiquinone), the largest of the respiratory complexes.
NDUFS8 is located on the q arm of chromosome 11 in position 13.2. [7] The NDUFS8 gene produces a 23.7 kDa protein composed of 210 amino acids. [10] [11] The encoded protein, TYKY, contains two 4Fe4S ferredoxin consensus patterns which are believed to be iron-sulfur cluster N-2 binding sites. [12]
The NDUFB8 protein weighs 22 kDa and is composed of 186 amino acids. [ 8 ] [ 9 ] NDUFB8 is a subunit of the enzyme NADH dehydrogenase (ubiquinone) , the largest of the respiratory complexes. The structure is L-shaped with a long, hydrophobic transmembrane domain and a hydrophilic domain for the peripheral arm that includes all the known redox ...