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Grover's disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis [2]: 529 with or without dyskeratosis. [3] Once confirmed, most cases of Grover's disease last six to twelve months, which is why it was originally called "transient". However it may last much longer.
Dyskeratosis is abnormal keratinization occurring prematurely within individual cells or groups of cells below the stratum granulosum. [ 1 ] Dyskeratosis congenita is congenital disease characterized by reticular skin pigmentation, nail degeneration, and leukoplakia on the mucous membranes associated with short telomeres .
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, [1] seen in diseases such as pemphigus vulgaris. [2]
A vesiculobullous disease is a type of mucocutaneous disease characterized by vesicles and bullae (i.e. blisters).Both vesicles and bullae are fluid-filled lesions, and they are distinguished by size (vesicles being less than 5–10 mm and bulla being larger than 5–10 mm, depending upon which definition is used).
Relapsing linear acantholytic dermatosis; Restrictive dermopathy X-linked ichthyosis; Rhizomelic chondrodysplasia punctata (autosomal recessive chondrodysplasia punctata type 1, chondrodystrophia calcificans punctata, peroxisomal biogenesis disorder complementation group 11) Rombo syndrome; Rothmund–Thomson syndrome (poikiloderma congenitale ...
Acantholytic cells, multinucleated giant cells and eosinophilic inclusion bodies 53.1 - 86% sensitive and 100% specific Hand, foot and mouth disease: Syncytial nuclei, absence of acantholytic cells 1: 72% sensitive and 100% specific Human papillomavirus infections: Koilocytes 75% sensitive and 100% specific Molluscum contagiosum
Acrokeratosis (AKV) is characterized by several small wart-like and flat-topped bumps that line the skin on typically the hand and feet. [7] Hypermelanotic macule. Dark patches on the skin that contain excess pigment. Subungual hyperkeratotic fragments. Thickened skin that is often discolored, under nails, on either hands or feet.
Acantholytic dyskeratotic epidermal nevus is a cutaneous condition identical to the generalized form of Darier's disease. [ 1 ] : 849 "Acantholytic dyskeratotic epidermal nevus" is probably the same disorder.