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In statistics, pooled variance (also known as combined variance, composite variance, or overall variance, and written ) is a method for estimating variance of several different populations when the mean of each population may be different, but one may assume that the variance of each population is the same. The numerical estimate resulting from ...
A paired difference test, better known as a paired comparison, is a type of location test that is used when comparing two sets of paired measurements to assess whether their population means differ. A paired difference test is designed for situations where there is dependence between pairs of measurements (in which case a test designed for ...
This is an example of a paired difference test. The t statistic is calculated as = ¯ /, where ¯ and are the average and standard deviation of the differences between all pairs. The pairs are e.g. either one person's pre-test and post-test scores or between-pairs of persons matched into meaningful groups (for instance, drawn from the same ...
The common example scenario for when a paired difference test is appropriate is when a single set of test subjects has something applied to them and the test is intended to check for an effect. Z-tests are appropriate for comparing means under stringent conditions regarding normality and a known standard deviation.
Variants include pooled cross-sectional data, which deals with the observations on the same subjects in different times. In a rolling cross-section , both the presence of an individual in the sample and the time at which the individual is included in the sample are determined randomly.
Here, = is the degrees of freedom associated with the i-th variance estimate. The statistic is approximately from the t -distribution since we have an approximation of the chi-square distribution . This approximation is better done when both N 1 {\displaystyle N_{1}} and N 2 {\displaystyle N_{2}} are larger than 5.
In a confirmatory or primary screen with replicates, for the i-th test compound with replicates, we calculate the paired difference between the measured value (usually on the log scale) of the compound and the median value of a negative control in a plate, then obtain the mean ¯ and variance of the paired difference across replicates.
Paired comparison analysis; Paired difference test; ... Pooled standard deviation – redirects to Pooled variance;