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Traditionally, CSF was evaluated mainly using invasive procedures such as lumbar puncture, myelographies, radioisotope studies, and intracranial pressure monitoring. Recently, rapid advances in imaging techniques have provided non-invasive methods for flow assessment.
Cisternography is a medical imaging technique to examine the flow of cerebrospinal fluid (CSF) in the brain, and spinal cord. [1] [2] The gold standard for diagnosis of a cranial cerebrospinal fluid leak is CT cisternography. [2] For the diagnosis of a spinal CSF leak radionuclide cisternography also known as radioisotope cisternography is used ...
Fluid-attenuated inversion recovery (FLAIR) is a magnetic resonance imaging sequence with an inversion recovery set to null fluids. For example, it can be used in brain imaging to suppress cerebrospinal fluid (CSF) effects on the image, so as to bring out the periventricular hyperintense lesions, such as multiple sclerosis (MS) plaques. [ 1 ]
In a study published in 2012, [5] a group of researchers from the University of Rochester, headed by Maiken Nedergaard, used in-vivo two-photon imaging of small fluorescent tracers to monitor the flow of subarachnoid CSF into and through the brain parenchyma. The two-photon microscopy allowed the Rochester team to visualize the flux of CSF in ...
Phase contrast-MRI is an imaging method that is more sensitive than MRI for analysis of the pulsatile CSF flow in the ventricular system. This method takes multiple images of the ventricles within one cardiac cycle to measure the flow of CSF running past the area of acquisition. If no flow is seen, this is a reliable diagnosis of aqueductal ...
The pathway and extent are currently not known, [1] but may involve CSF flow along some cranial nerves and be more prominent in the neonate. [3] CSF turns over at a rate of three to four times a day. [2] CSF has also been seen to be reabsorbed through the sheathes of cranial and spinal nerve sheathes, and through the ependyma. [3]
In a mouse study, researchers found that zolpidem (Ambien), a common sleep aid, could prevent the brain from effectively clearing up 'waste', though it remains unclear whether this could affect ...
ShuntCheck flow data, used in conjunction with other diagnostic test results and with physician judgment, can aid in ruling in or ruling out shunt obstruction. [1] A tool for establishing “normal” CSF flow patterns in asymptomatic patients. Establishing baseline flow may increase the value of flow information in symptomatic patients. [1]