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The exact mechanism of action of silicone gel sheeting has not been fully studied. Currently, many proposed mechanisms explain the efficacy of such treatment, including the occlusion and hydration effect, increased body surface temperature, polarized electric charge, immunological effects, etc. [9] The occlusion and hydration effect is the most studied mechanism of action.
Mederma is a topical product used to improve scar appearance. It is a gel based on an onion extract. Mederma is product of HRA Pharma, a division of Perrigo. A Mederma marketing claim is that the product can can make scars "softer, smoother, and less noticeable". [1]
Silicone scar treatments are commonly used in preventing scar formation and improving existing scar appearance. [50] A meta-study by the Cochrane collaboration found weak evidence that silicone gel sheeting helps prevent scarring. [51] However, the studies examining it were of poor quality and susceptible to bias. [51]
Silicone gel sheets may improve the appearance of scars slightly compared with applying onion extract, and may reduce pain compared with no treatment with silicone gel sheets or pressure garments. [8] It is uncertain whether silicone gel sheets are more effective than other treatment approaches. [8]
In its uncured state, silicone rubber is a highly adhesive gel or liquid. To convert it to a solid, it must be cured, vulcanized, or catalyzed.This is normally carried out in a two-stage process at the point of manufacture into the desired shape, and then in a prolonged post-cure process.
Another 2022 systematic review compared silicone gel sheeting with no treatment, treatment with non-silicone gel sheeting and treatment with intralesional injections of triamcinolone acetonide. The authors only found two small studies (36 participants in total) that compared these treatment options so were unable to determine which (if any) was ...