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This is a list of progestogens (progesterone and progestins) and formulations that are approved by the FDA Tooltip Food and Drug Administration in the United States. . Progestogens are used as hormonal contraceptives, in hormone replacement therapy for menopausal symptoms, and in the treatment of gynecological
Ethinylestradiol/gestodene (EE/GSD), sold under the brand names Femodene and Minulet among others, is a combination of ethinylestradiol (EE), an estrogen, and gestodene (GSD), a progestin, which is used as a birth control pill to prevent pregnancy in women. [1] [2] It is taken by mouth and contains 20 or 30 μg EE and 0.075 mg GSD per tablet.
These differences make EE more favorable for use in birth control pills than estradiol, though also result in an increased risk of blood clots and certain other rare adverse effects. [7] EE was developed in the 1930s and was introduced for medical use in 1943. [13] [14] The medication started being used in birth control pills in the 1960s. [15]
Estradiol, mainly as esters including estradiol valerate, estradiol cypionate, and estradiol enanthate, is also the exclusive estrogen used in combined injectable contraceptives. [6] As of 2021, more than 95% of prescriptions are for combined hormonal birth control forms containing the synthetic estrogen ethinylestradiol (EE). [7]
Norelgestromin/ethinylestradiol, sold under the brand name Ortho Evra among others, is a contraceptive patch containing the progestin norelgestromin and the estrogen ...
Estradiol-containing birth control pills were initially studied in the 1970s, with the first report published in 1977. [230] [231] Development of birth control pills containing estradiol was motivated by the thrombotic risks of ethinylestradiol that were uncovered in the 1960s and 1970s.
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