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The macula (/ˈmakjʊlə/) [1] or macula lutea is an oval-shaped pigmented area in the center of the retina of the human eye and in other animals. The macula in humans has a diameter of around 5.5 mm (0.22 in) and is subdivided into the umbo, foveola, foveal avascular zone, fovea, parafovea, and perifovea areas.
The most common gene mutation is the FH phenotype and has a 67.5% correlation rate to macular hypoplasia. [7] The disorder can occur through two distinct genetic abnormalities. [8] The difference among mutated genes results in a difference in phenotypic display of macular hypoplasia. [8] In phenotype FVH1, there is a mutation of the PAX6 gene. [8]
The foveola is located within a region called the macula, a yellowish, cone photoreceptor filled portion of the human retina.Approximately 0.35 mm in diameter, the foveola lies in the center of the fovea and contains only cone cells and a cone-shaped zone of Müller cells. [1]
The difference between the two forms is categorized by the change in the macula. Those with dry-form AMD have drusen, cellular debris in their macula that gradually damages light-sensitive cells and leads to vision loss. In wet-form AMD, blood vessels grow under the macula, causing blood and fluid to leak into the retina. [4]
The macula has a yellow pigmentation, from screening pigments, and is known as the macula lutea. The area directly surrounding the fovea has the highest density of rods converging on single bipolar cells. Since its cones have a much lesser convergence of signals, the fovea allows for the sharpest vision the eye can attain. [2]
Diagram of the human eye showing macula and fovea. Although J. D. Gass originally identified four types of idiopathic juxtafoveolar retinal telangiectasis in 1982, contemporary researchers describe three types collectively known as idiopathic juxtafoveal telangiectasia: macular telangiectasia type 1, macular telangiectasia type 2, and macular telangiectasia type 3.
The spot to the left of the centre is the macula. The grey, more diffuse spot in the centre is a shadow artifact. The fundus of the eye is the interior surface of the eye opposite the lens and includes the retina, optic disc, macula, fovea, and posterior pole. [1] The fundus can be examined by ophthalmoscopy [1] and/or fundus photography.
Photograph of the retina of the human eye, with overlay diagrams showing the positions and sizes of the macula, fovea, and optic disc. Perifovea is a region in the retina that circumscribes the parafovea and fovea and is a part of the macula lutea. [1] The perifovea is a belt that covers a 10° radius around the fovea and is 1.5 mm wide.