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[2] [3] It is analogous to andropause in men and menopause in women, the abrupt or gradual decline in production of sex hormones from the gonads with age. [4] DHEA can be supplemented or taken as a medication in the form of prasterone to replace adrenal androgens later in life if it is desired. [2]
In males, normal aging causes a decrease in androgens, which is sometimes called "male menopause" (also known by the coinage "manopause"), late-onset hypogonadism (LOH), and "andropause" or androgen decline in the aging male (ADAM), among other names. It is a symptom of hereditary hemochromatosis [5]
Levels of DHEA-S in circulation are approximately 250 to 300 times those of DHEA. [20] DHEA-S in turn can be converted back into DHEA in peripheral tissues via steroid sulfatase (STS). [54] [55] The terminal half-life of DHEA is short at only 15 to 30 minutes. [56] In contrast, the terminal half-life of DHEA-S is far longer, at 7 to 10 hours. [56]
DHEA can be lower in people with depression and after menopause, and levels tend to decrease as you age. At age 70 to 80 , DHEA levels may be down to 10 to 20 percent of those in a younger person.
The 1997 book Male Menopause [17] [18] by Jed Diamond, a psychologist with a PhD in international health, [19] fueled popular interest in the concept of "andropause". [citation needed] Diamond regards andropause as a change of life in middle-aged men which has hormonal, physical, psychological, interpersonal, social, sexual, and spiritual ...
Prasterone, also known as dehydroepiandrosterone (DHEA) and sold under the brand name Intrarosa among others, is a medication as well as over-the-counter dietary supplement which is used to correct DHEA deficiency due to adrenal insufficiency or old age, as a component of menopausal hormone therapy, to treat painful sexual intercourse due to vaginal atrophy, and to prepare the cervix for ...