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A box model explaining the processes of toxicokinetics and toxicodynamics. While toxicokinetics describes the changes in the concentrations of a toxicant over time due to the uptake, biotransformation, distribution and elimination of toxicants, toxicodynamics involves the interactions of a toxicant with a biological target and the functional or structural alterations in a cell that can ...
It is an application of pharmacokinetics to determine the relationship between the systemic exposure of a compound and its toxicity.It is used primarily for establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans.
Wikibooks is an open-source wiki-based Wikimedia project hosted by the Wikimedia Foundation for the creation of free content digital textbooks and annotated texts that anyone can edit. As of December 2024, Wikibooks book modules have been created in 121 editions, with 77 currently active and 44 closed.
Growth of the eight largest Wikibooks sites (by language), July 2003–January 2010. Wikibooks (previously called Wikimedia Free Textbook Project and Wikimedia-Textbooks) is a wiki-based Wikimedia project hosted by the Wikimedia Foundation for the creation of free content digital textbooks and annotated texts that anyone can edit.
Jurn is a free-to-use online search tool for finding and downloading free full-text scholarly works. In 2014 Jurn expanded beyond open access journals in the arts and humanities, to also index open journals in ecology, science, biomedical, business and economics. Jurn is actively curated and maintained. Free Jurn [87] L'Année philologique
Over 1,200 (and growing) books published by the Metropolitan Museum of Art, New York, up to c. 2009, fully available to download as PDFs (though content is still copyrighted) from the Thomas J. Watson Library at the MMA.
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Toxicodynamics (TD) and pharmacodynamics (PD) link a therapeutic agent or toxicant, or toxin (xenobiotic)'s dosage to the features, amount, and time course of its biological action. [11] The mechanism of action is a crucial factor in determining effect and toxicity of the drug, taking in consideration the pharmacokinetic (PK) factors. [12]