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Brain simulation projects intend to contribute to a complete understanding of the brain, and eventually also assist the process of treating and diagnosing brain diseases. [ 2 ] [ 3 ] Simulations utilize mathematical models of biological neurons , such as the hodgkin-huxley model , to simulate the behavior of neurons , or other cells within the ...
Creating a cellular model has been a particularly challenging task of systems biology and mathematical biology. It involves the use of computer simulations of the many cellular subsystems such as the networks of metabolites, enzymes which comprise metabolism and transcription, translation, regulation and induction of gene regulatory networks. [4]
The brain's large-scale organizational principles are illuminated by many fields, including biology, psychology, and clinical practice. Integrative neuroscience attempts to consolidate these observations through unified descriptive models and databases of behavioral measures and recordings. These are the bases for some quantitative modeling of ...
Computational biology refers to the use of techniques in computer science, data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. [1] An intersection of computer science , biology , and data science , the field also has foundations in applied mathematics , molecular biology , cell ...
The theta model, or Ermentrout–Kopell canonical Type I model, is mathematically equivalent to the quadratic integrate-and-fire model which in turn is an approximation to the exponential integrate-and-fire model and the Hodgkin-Huxley model. It is called a canonical model because it is one of the generic models for constant input close to the ...
A traditional model of a biological system will focus on capturing its most important parameters. In contrast, an alife modeling approach will generally seek to decipher the most simple and general principles underlying life and implement them in a simulation. The simulation then offers the possibility to analyse new and different lifelike systems.
Computational cognition (sometimes referred to as computational cognitive science or computational psychology or cognitive simulation) is the study of the computational basis of learning and inference by mathematical modeling, computer simulation, and behavioral experiments. In psychology, it is an approach which develops computational models ...
Biosimulation is becoming increasingly important for drug development. [1] Since on average only 11% of all drug candidates are approved, [2] it is anticipated that biosimulation may be the tool to predict whether a candidate drug will fail in the development process e.g. in clinical trials due to adverse side effects, bad pharmacokinetics or even toxicity.