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Daratumumab, sold under the brand name Darzalex among others, is an anti-cancer monoclonal antibody medication. It binds to CD38 , [ 7 ] which is overexpressed in multiple myeloma cells. [ 8 ]
It was approved for use in the United States in May 2020. [2] [7] [8]Efficacy of daratumumab and hyaluronidase-fihji (monotherapy) was evaluated in the COLUMBA trial (NCT03277105), an open-label non-inferiority trial randomizing 263 participants to daratumumab and hyaluronidase-fihj and 259 to intravenous daratumumab (daratumumab IV). [2]
cryopyrin-associated periodic syndrome, Yao's Syndrome, Adult Onset Still's Disease: Cantuzumab mertansine [42] mab: humanized: CanAg (a glycoform of MUC1) colorectal cancer etc. Cantuzumab ravtansine [42] mab: humanized: CanAg (a glycoform of MUC1) cancers Caplacizumab [44] Cablivi: sdAb: humanized: VWF: Y: thrombotic thrombocytopenic purpura ...
Treatment of adults with advanced, unresectable or metastatic non-small cell lung cancer harboring a neuregulin 1 (NRG1) gene fusion with disease progression on or after prior systemic therapy; and adults with advanced, unresectable or metastatic pancreatic adenocarcinoma harboring an NRG1 gene fusion with disease progression on or after prior ...
Immunosuppressants have seen use at low doses alongside systemic steroids and phototherapy for chronic symptoms of senile pruritus or dermatitis. Senile pruritus could have connections to the loss of tolerance for antigens on the skin that result from aging skin, which can potentially lead to other autoimmune disorders like bullous pemphigoid .
From January 2008 to December 2012, if you bought shares in companies when Bobby S. Shackouls joined the board, and sold them when he left, you would have a -2.9 percent return on your investment, compared to a -2.8 percent return from the S&P 500.
Some common symptoms and signs of mastoiditis include pain, tenderness, and swelling in the mastoid region. There may be ear pain , and the ear or mastoid region may be red (erythematous). Fever or headaches may also be present. Infants usually show nonspecific symptoms, including anorexia, diarrhea, or irritability. Drainage from the ear ...
About 21 million U.S. adults in 2021 experienced at least one depressive episodes, latest government data shows. J&J said that about a third of adults will not respond to oral antidepressants alone.
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