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Alcohol binds to several different subtypes of GABA A, but not to others. The main subtypes responsible for the subjective effects of alcohol are the α 1 β 3 γ 2, α 5 β 3 γ 2, α 4 β 3 δ and α 6 β 3 δ subtypes, although other subtypes such as α 2 β 3 γ 2 and α 3 β 3 γ 2 are also affected. Activation of these receptors causes ...
Blood alcohol content (BAC), also called blood alcohol concentration or blood alcohol level, is a measurement of alcohol intoxication used for legal or medical purposes. [1] BAC is expressed as mass of alcohol per volume of blood. In US and many international publications, BAC levels are written as a percentage such as 0.08%, i.e. there is 0.8 ...
In addition to the toxicity of ethanol, the main psychoactive component of alcoholic beverages, other physiological symptoms may arise from the activity of acetaldehyde, a metabolite of alcohol. [11] These effects may not arise until hours after ingestion and may contribute to a condition colloquially known as a hangover .
Per the American Heart Association (AHA), alcohol is one of the leading causes of dilated cardiomyopathy. [2] However, multiple longitudinal studies have shown a paradoxical lowering of dilated cardiomyopathy with modest-to-moderate alcohol consumption. [2] ACM is a type of heart disease that occurs due to chronic alcohol consumption.
The three disease types are drug overdose (including alcohol overdose), suicide, and alcoholic liver disease. Diseases of despair, and the resulting deaths of despair , are high in the Appalachian region [ 1 ] of the United States, especially in Pennsylvania , West Virginia , and Delaware . [ 2 ]
[2] Treatment is generally with intravenous normal saline and intravenous sugar solution. [2] Thiamine and measures to prevent alcohol withdrawal are also recommended. [2] Treatment of low blood potassium may also be required. [2] Those who are affected are most frequently between the ages of 20 and 60. [2]
The CDC found alcohol-induced deaths jumped 26% between 2019 and 2020, killing more than 49,000 people during the first year of the pandemic. Alcoholic liver disease was the leading cause of ...
Alcohol intoxication is graded in intensity from buzzed, to tipsy then drunk all the way up to hammered, plastered, smashed, wasted, destroyed, shitfaced and a number of other terms. The term rolling is a common word used to describe being under the influence of MDMA and for LSD the phrases frying or tripping have been used.
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