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Sodium/glucose cotransporter 1 (SGLT1) also known as solute carrier family 5 member 1 is a protein in humans that is encoded by the SLC5A1 gene [4] [5] which encodes the production of the SGLT1 protein to line the absorptive cells in the small intestine and the epithelial cells of the kidney tubules of the nephron for the purpose of glucose uptake into cells. [6]
SLC5A4, also known as SGLT3, is a member of the sodium-glucose cotransporter family. Unlike SGLT1 and SGLT2, which are efficient glucose transporters, SGLT3 functions primarily as a glucose sensor rather than a transporter. It has a low affinity for glucose and does not significantly contribute to glucose transport across cell membranes.
Na + /glucose cotransporter (SGLT1) – is also known as sodium-glucose cotransporter 1 and is encoded by the SLC5A1 gene. SGLT1 is an electrogenic transporter as the sodium electrochemical gradient drives glucose uphill into the cells.
In August 1960, in Prague, Crane presented for the first time his discovery of the sodium-glucose cotransport as the mechanism for intestinal glucose absorption. [3] Cotransport was the first ever proposal of flux coupling in biology and was the most important event concerning carbohydrate absorption in the 20th century.
low-glucose sensor; repressed by glucose; low expression level; repressor of Hxt6: Rgt2: high-glucose sensor; low expression level Hxt1: Km: 100 mM, [3] 129 - 107 mM [1] low-affinity glucose transporter; induced by high glucose level Hxt2: Km = 1.5 [1] - 10 mM [3] high/intermediate-affinity glucose transporter; induced by low glucose level [3] Hxt3
It is an integral membrane protein carrier with a hydrophilic interior, which allows it to bind to glucose. As GLUT 1 is a type of carrier protein, it will undergo a conformational change to allow glucose to enter the other side of the plasma membrane. [22] GLUT 1 is commonly found in the red blood cell membranes of mammals. [23]
When it comes to food storage and safety, it can be hard to keep things straight, especially with produce.Some fruits, like berries and grapes, should definitely be refrigerated, while others ...
[1] [2] Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee ( HGNC ) and is the basis for the official HGNC names of the genes that encode these transporters.