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Transforming growth factor-β (TGF-β) is a superfamily of cytokines that play a significant upstream role in regulating of morphogenesis, homeostasis, cell proliferation, and differentiation. [2] The significance of TGF-β is apparent with the human diseases that occur when TGF-β processes are disrupted, such as cancer, and skeletal ...
The 3 core sciences namely Biology, Chemistry, and Physics will be updated for first teaching in August 2023, with first examinations in May 2025. The syllabus change was originally scheduled for 2021, though the COVID-19 pandemic caused the IB to delay the syllabus change to 2023. Details of the specific changes can be found on the IBO website.
Sir John Vane in 1952 Sir John Robert Vane FRS (1927-2004); 1944 - chemistry degree at the University of Birmingham [100]; 1946-1949 - student in pharmacology in Oxford under J.H. Burn with research into acetylcholine [101] and paludrine [102]; 1949-1953 – doctorate with Dawes in the Nuffield Institute; 1953-1955 – Assistant Professor under ...
An upstream activating sequence or upstream activation sequence (UAS) is a cis-acting regulatory sequence found in yeast like Saccharomyces cerevisiae. It is distinct from the promoter and increases the expression of a neighbouring gene .
The upstream part of a bioprocess refers to the first step in which microbes/cells are grown, e.g. bacterial or mammalian cell lines (see cell culture), in bioreactors. Upstream processing involves all the steps related to inoculum development, media development, improvement of inoculum by genetic engineering process, optimization of growth ...
The S1 domain is a protein domain that was originally identified in ribosomal protein S1 but is found in a large number of RNA-associated proteins. The structure of the S1 RNA-binding domain from the Escherichia coli polynucleotide phosphorylase has been determined using NMR methods and consists of a five-stranded antiparallel beta barrel.
Molecular biology. Upstream and downstream (DNA), determining relative positions on DNA; Upstream and downstream (transduction) ...
An upstream open reading frame (uORF) is an open reading frame (ORF) within the 5' untranslated region (5'UTR) of an mRNA. uORFs can regulate eukaryotic gene expression. [1] [2] Translation of the uORF typically inhibits downstream expression of the primary ORF. However, in some genes such as yeast GCN4, translation of specific uORFs may ...