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A sarcoma is a malignant tumor, a type of cancer that arises from cells of mesenchymal (connective tissue) origin. [1] [2] Connective tissue is a broad term that includes bone, cartilage, muscle, fat, vascular, or other structural tissues, and sarcomas can arise in any of these types of tissues.
It is the most common soft tissue sarcoma occurring in children. [1] Embryonal rhabdomyosarcoma is also known as PAX-fusion negative or fusion-negative rhabdomyosarcoma, as tumors of this subtype are unified by their lack of a PAX3 - FOXO1 fusion oncogene (or other PAX fusions seen in alveolar rhabdomyosarcoma ).
Rhabdomyosarcoma is the most common soft-tissue sarcoma in children as well as the third most common solid tumor in children. Recent estimates place the incidence of the disease at approximately 4.5 case per 1 million children/adolescents with approximately 250 new cases in the United States each year.
A diagnosis of uterine sarcoma may be suspected based on symptoms, a pelvic exam, and medical imaging. [2] Endometrial cancer can often be cured while uterine sarcoma typically is harder to treat. [3] Treatment may include a combination of surgery, radiation therapy, chemotherapy, hormone therapy, and targeted therapy.
Four main hypotheses have been proposed for the cellular origins of carcinosarcoma, based largely on the pathology of the disease. [1] [3] First, the collision tumor hypothesis, which proposes the collision of two independent tumors resulting in a single neoplasm, based on the observation that skin cancers and superficial malignant fibrous histiocytomas are commonly seen in patients with sun ...
The way a person responds to pain affects the intensity of their pain (moderately), the degree of disability they experience, and the impact of pain on their quality of life. Strategies employed by people to cope with cancer pain include enlisting the help of others; persisting with tasks despite pain; distraction; rethinking maladaptive ideas ...
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