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This combination drug is sold as Daktacort in UK, [1] Daktodor in Greece and Cortimyc in Sweden. In Denmark it is available as Brentacort . Indications include irritant diaper dermatitis .
Lofentanil or lofentanyl is one of the most potent opioid analgesics known and is an analogue of fentanyl, which was developed in 1960.It is most similar to the highly potent opioid carfentanil (4-carbomethoxyfentanyl), only slightly more potent.
Hydrocortisone is the pharmaceutical term for cortisol used in oral administration, intravenous injection, or topical application.It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients needing steroid treatment but unable to take oral medication, and perioperatively in ...
After application to the skin, miconazole can be measured in the skin for up to four days, but less than 1% is absorbed into the bloodstream. When applied to the oral mucosa (and possibly also for vaginal use [9]), it is significantly absorbed. In the bloodstream, 88.2% are bound to plasma proteins and 10.6% to blood cells.
Weaker topical steroids are utilized for thin-skinned and sensitive areas, especially areas under occlusion, such as the armpit, groin, buttock crease, and breast folds.. Weaker steroids are used on the face, eyelids, diaper area, perianal skin, and intertrigo of the groin or body fo
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
Bicalutamide also shows a better safety profile than cyproterone acetate. When used as a high-dosage monotherapy, bicalutamide shows slightly inferior effectiveness in the treatment of prostate cancer compared to castration and GnRH analogues but a different and potentially superior tolerability and safety profile.
Bulk moduli, shear moduli, and elasticity are the key factors in the superhard classification process. The incompressibility of a material is quantified by the bulk modulus B, which measures the resistance of a solid to volume compression under hydrostatic stress as B = −Vdp/dV.