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Most textbooks make a distinction between the nuclear genome and the organelle (mitochondria and chloroplast) genomes so when they speak of, say, the human genome, they are only referring to the genetic material in the nucleus. [2] [15] This is the most common use of 'genome' in the scientific literature.
While the word genome (from the German Genom, attributed to Hans Winkler) was in use in English as early as 1926, [11] the term genomics was coined by Tom Roderick, a geneticist at the Jackson Laboratory (Bar Harbor, Maine), over beers with Jim Womack, Tom Shows and Stephen O’Brien at a meeting held in Maryland on the mapping of the human ...
Genes are then duplicated to form multigene families which duplicate to form superfamilies spanning multiple chromosomes. Whole genome duplication doubles the number of copies of every gene and gene family. [6] Whole genome duplication or polyploidization can be either autopolyploidization or alloploidization. Autopolyploidization is the ...
Whereas a genome sequence lists the order of every DNA base in a genome, a genome map identifies the landmarks. A genome map is less detailed than a genome sequence and aids in navigating around the genome. [75] [76] An example of a variation map is the HapMap being developed by the International HapMap Project.
The first plant genome – that of the model organism Arabidopsis thaliana – was also fully sequenced by 2000. [21] By 2001, a draft of the entire human genome sequence was published. [22] The genome of the laboratory mouse Mus musculus was completed in 2002. [23] In 2004, the Human Genome Project published an incomplete version of the human ...
[1] Paleopolyploidy is the result of genome duplications which occurred at least several million years ago (MYA). Such an event could either double the genome of a single species (autopolyploidy) or combine those of two species (allopolyploidy). Because of functional redundancy, genes are rapidly silenced or lost from the duplicated genomes.
Junk DNA (non-functional DNA) is a DNA sequence that has no known biological function. [1] [2] Most organisms have some junk DNA in their genomes—mostly, pseudogenes and fragments of transposons and viruses—but it is possible that some organisms have substantial amounts of junk DNA.
Typical mammalian protein-coding genes, for example, are about 62,000 base pairs in length (transcribed region) and since there are about 20,000 of them they occupy about 35–40% of the mammalian genome (including the human genome). [18] [19] [20]