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A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1]
It is made from pregnenolone, and is a positive allosteric modulator of the action of γ-aminobutyric acid (GABA) at GABA A receptor. [10] Allopregnanolone has effects similar to those of other positive allosteric modulators of the GABA action at GABA A receptor such as the benzodiazepines, including anxiolytic, sedative, and anticonvulsant ...
The company manufactures the Sleep Number® bed, an adjustable air mattress.The "Sleep Number® setting" is a setting that adjusts the firmness or softness of the mattress on each side of the bed using air pressure (dual air chambers, one on each side), with higher numbers (up to 100) denoting higher pressure and more firmness, and lower numbers denoting less pressure and more softness.
β-Aminobutyric acid (BABA) is an isomer of the amino acid aminobutyric acid with the chemical formula C 4 H 9 NO 2.It has two isomers, α-aminobutyric acid and γ-aminobutyric acid (GABA), a neurotransmitter in animals that is also found in plants, where it may play a role in signalling.
In pharmacology, GABA A receptor positive allosteric modulators, also known as GABAkines or GABA A receptor potentiators, [1] are positive allosteric modulator (PAM) molecules that increase the activity of the GABA A receptor protein in the vertebrate central nervous system. GABA is a major inhibitory neurotransmitter in the central nervous system.
Valerenic acid acts as a subtype-selective GABA A receptor positive allosteric modulator via a binding site in the transmembrane domain at the β + α − interface. [4] At receptors expressed in Xenopus oocytes (frog eggs) it was shown that only assemblies incorporating β2 or β3 subunits were stimulated by valerenic acid.