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  2. Melatonin as a medication and supplement - Wikipedia

    en.wikipedia.org/wiki/Melatonin_as_a_medication...

    [43] [44] Prolonged-release melatonin is safe with long-term use of up to 12 months. [11] Although not recommended for long-term use beyond this, [45] low-dose melatonin is generally safer, and a better alternative, than many prescription and over-the-counter sleep aids if a sleeping medication must be used for an extended period of time.

  3. Hypnotic - Wikipedia

    en.wikipedia.org/wiki/Hypnotic

    Zolpidem tartrate, a common but potent sedative–hypnotic drug.Used for severe insomnia. Hypnotic (from Greek Hypnos, sleep [1]), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep [2] (or surgical anesthesia [note 1]) and to treat insomnia (sleeplessness).

  4. Advanced sleep phase disorder - Wikipedia

    en.wikipedia.org/wiki/Advanced_sleep_phase_disorder

    Sleep specialists measure the patient's sleep onset and offset, dim light melatonin onset, and evaluate Horne-Ostberg morningness-eveningness questionnaire results. Sleep specialists may also conduct a polysomnography test to rule out other sleep disorders like narcolepsy. Age and family history of the patient is also taken into consideration. [2]

  5. Hyperekplexia - Wikipedia

    en.wikipedia.org/wiki/Hyperekplexia

    The hypertonia may be predominantly truncal, attenuated during sleep, or less prominent after one year of age. Classic hyperekplexia is caused by genetic mutations in a number of different genes, all of which play an important role in glycine neurotransmission. Glycine is used by the central nervous system as an

  6. Glycine - Wikipedia

    en.wikipedia.org/wiki/Glycine

    Glycine (symbol Gly or G; [6] / ˈ ɡ l aɪ s iː n / ⓘ) [7] is an amino acid that has a single hydrogen atom as its side chain. It is the simplest stable amino acid ( carbamic acid is unstable). Glycine is one of the proteinogenic amino acids .

  7. Glycine receptor - Wikipedia

    en.wikipedia.org/wiki/Glycine_receptor

    In mature adults, glycine is a inhibitory neurotransmitter found in the spinal cord and regions of the brain. [15] As it binds to a glycine receptor, a conformational change is induced, and the channel created by the receptor opens. [17] As the channel opens, chloride ions are able to flow into the cell which results in hyperpolarization.

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