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Human genetic variants that likely cause dysregulation of critical meiotic processes have been identified in 14 female infertility associated genes. [53] A major cause of female infertility is premature ovarian insufficiency. [54] This insufficiency is a heterogeneous disease that affects about 1% of women who are under the age of 40. [54]
Male infertility is responsible for 20–30% of infertility cases, while 20–35% are due to female infertility, and 25–40% are due to combined problems in both partners. [29] [5] In 10–20% of cases, no cause is found. [5] The most common cause of female infertility are ovulation problems, usually manifested by scanty or absent menstrual ...
Epigenetic alterations of the aromatase-encoding gene (CYP19A1) may cause deregulation in cumulus cells in infertile women with endometriosis, leading to altered ovarian follicles and impaired oocyte quality. [17] For other unknown reasons, endometriosis is more likely to develop in infertile women, and thus be a secondary phenomenon. [21]
Tubal factors cause 25-30% of infertility cases. [1] Tubal factor is one complication of chlamydia trachomatis infection in women. [2] Sexually transmitted chlamydia and genital mycoplasma infections are preventable causes of infertility and negative pregnancy outcomes. When the infections progress and ascend, they can result in TFI.
Chronic anovulation is a common cause of infertility. In addition to the alteration of menstrual periods and infertility, chronic anovulation can cause or exacerbate other long-term problems, such as hyperandrogenism or osteopenia. It plays a central role in the multiple imbalances and dysfunctions of polycystic ovary syndrome.
It can cause irregular periods, ovarian cysts, insulin resistance, facial hair growth and infertility. The idea to take my husband, Phin, to OB-GYN appointments came up after a particularly bad ...
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