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PLMD is characterized by increased periodic limb movements during sleep, which must coexist with a sleep disturbance or other functional impairment, in an explicit cause-effect relationship. [ 3 ] [ 4 ] Usually, these involuntary movements come from lower extremities (including toes, ankles, knees, and hips), although they can also be observed ...
Most RMD symptoms are relatively passive and do not cause any pain. Many patients are often unaware that an episode is occurring or has occurred. The rhythmic movements may produce some bodily injury via falls or muscle strains, but this is not reported in all patients [4]. In unique cases of RMD, they hum or moan while asleep during an episode.
A cramp is a sudden, involuntary, painful skeletal muscle contraction [1] [2] or overshortening associated with electrical activity; [3] while generally temporary and non-damaging, they can cause significant pain and a paralysis-like immobility of the affected muscle.
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Charley horses have many possible causes directly resulting from high or low pH or substrate concentrations in the blood, including hormonal imbalances, dehydration, low levels of magnesium, potassium, or calcium (evidence has been mixed), [5] [6] [7] side effects of medication, or, more seriously, diseases such as amyotrophic lateral sclerosis and neuropathy. [8]