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A branded version called Cortrosyn, which was created and developed by Organon and was approved by the FDA in 1970, and as of January 2017 was under the control of Amphastar Pharmaceuticals, [24] [25] and there were three generic versions under ANDAs, one for Mylan approved in 2009, [26] one for Sandoz/Novartis, approved in 2012, [27] and ...
The ACTH test (also called the cosyntropin, tetracosactide, or Synacthen test) is a medical test usually requested and interpreted by endocrinologists to assess the functioning of the adrenal glands' stress response by measuring the adrenal response to adrenocorticotropic hormone (ACTH; corticotropin) or another corticotropic agent such as tetracosactide (cosyntropin, tetracosactrin; Synacthen ...
The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent. Elitek (rasburicase) is supplied in 3 mL and 10 mL colorless, glass vials containing rasburicase at a concentration of 1.5 mg/mL after reconstitution.
Immune reconstitution inflammatory syndrome (IRIS) is a condition seen in some cases of HIV/AIDS or immunosuppression, in which the immune system begins to recover, but then responds to a previously acquired opportunistic infection with an overwhelming inflammatory response that paradoxically makes the symptoms of infection worse. [1]
After thawing, single units of cryo (or units pooled using a sterile method) can be stored at 20–24 °C for up to 6 hours. If units of cryo are pooled in an open system, they can only be held at 20–24 °C for up to 4 hours. [3] Presently cryo cannot be re-frozen for storage after it is thawed for use if it is not transfused.
The specific activity of highly purified human enzyme is 890,000 units/mg, [5] meanwhile the enzyme activity produced by recombinant DNA technology is approximately 40 units/mg. [6] A typical dose is 2.5U/kg every two weeks, up to a maximum of 60 U/kg once every two weeks, and safety has been established from ages 2 and up. [7]
Clinical improvements can be observed at Week 24 of treatment, [46] [47] [48] and benefits may be sustained up to 4 years, beyond the 2-year dosing period and recovery of total lymphocytes. [44] [49] [50] Post-hoc analyses of clinical trial data showed that 89% of patients remained free from disability progression two years after treatment. [51]
The suggested concentration is 1-10 μM (0.5-5 μg/ml). Leupeptin is an organic compound produced by actinomycetes , which inhibits serine , cysteine and threonine proteases . Leupeptin inhibits serine proteinases ( trypsin (K i =3.5 nM), plasmin (K i = 3.4 nM), porcine kallikrein ), and cysteine proteinases ( papain , cathepsin B (K i = 4.1 nM ...