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aP2 (adipocyte Protein 2) [5] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs [6] has the possibility of treating heart disease and the metabolic syndrome. [7]
Hence, inhibition of the HIV protease is one of the most important approaches for the therapeutic intervention in HIV infection [2] and their development is regarded as major success of structure-based drug design. [3] They are highly effective against HIV [4] and have, since the 1990s, been a key component of anti-retroviral therapies for HIV ...
The adipose differentiation related protein (ADRP) was first characterized as an mRNA molecule that express early in adipocyte differentiation. [8] The full length cDNA was cloned by rapid amplification of cDNA ends method and sequence analysis results in a protein with 425 amino acids that is unique and similar sequences had not previously been reported.
The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. [ 1 ] [ 2 ] These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes . [ 3 ]
Group XVI phospholipase A2 also commonly known as adipocyte phospholipase A2 (AdPLA) is an enzyme that in humans is encoded by the PLA2G16 gene. [ 1 ] [ 2 ] [ 3 ] This enzyme has also been identified as PLA2G16, HRASLS3, HREV107, HREV107-3, MGC118754 or H-REV107-1 from studies on class II tumor suppression but not on its enzymatic properties. [ 4 ]
16890 Ensembl ENSG00000079435 ENSMUSG00000003123 UniProt Q05469 P54310 RefSeq (mRNA) NM_005357 NM_001039507 NM_010719 RefSeq (protein) NP_005348 NP_001034596 NP_034849 Location (UCSC) Chr 19: 42.4 – 42.43 Mb Chr 7: 25.08 – 25.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein family Hormone-sensitive lipase (HSL) N-terminus Identifiers Symbol HSL_N Pfam PF06350 InterPro ...
Perilipin, also known as lipid droplet-associated protein, perilipin 1, or PLIN, is a protein that, in humans, is encoded by the PLIN gene. [5] The perilipins are a family of proteins that associate with the surface of lipid droplets. Phosphorylation of perilipin is essential for the mobilization of fats in adipose tissue. [6]
These genes include adipocyte protein (aP2), insulin receptor, glycerophosphate dehydrogenase, fatty acid synthase, acetyl CoA carboxylase, glucose transporter type 4 (Glut 4) and so on. [6] Through this process, lipid droplets accumulate in the adipocyte .