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Cryptorchidism, also known as undescended testis, is the failure of one or both testes to descend into the scrotum. The word is from Ancient Greek ...
The lower part persists as the gubernaculum testis ("scrotal ligament"). This ligament secures the testis to the most inferior portion of the scrotum, tethering it in place and limiting the degree to which the testis can move within the scrotum. Cryptorchidism (undescended testes) are observed in INSL3-null male mice.
The ectopic testis can be in the perineal region, the opposite side of the scrotum, the suprapubic region, the femoral region, or the superficial inguinal pouch. [1]The ectopic testis is initially normal, but if it is ignored after childhood, it may become small and soft, with spermatogenesis arresting and interstitial cell proliferation occurring.
The descent of the testicles consists of the opening of a connection from the testis to its final location at the anterior abdominal wall, followed by the development of the gubernaculum, which subsequently pulls and translocates the testicle down into the developing scrotum. Ultimately, the passageway closes behind the testis.
It carries with it the ductus deference, which are testicular vessels and nerves, a portion of the abdominal muscle, and lymph vessels. All of the structures remain attached to the testis and form what is known as the spermatic cord. By the time the testis is in the scrotal sac, the gubernaculum is no more than a remnant of scar like tissue. [10]
In the inguinal crest of a peculiar structure, the gubernaculum testis makes its appearance. This is at first a slender band, extending from that part of the skin of the groin which afterward forms the scrotum through the inguinal canal to the body and epididymis of the testis .
The tunica vasculosa testis (vascular layer of testis) is the inner-most of the three layers that form the capsule of the testis. It consists of a vascular plexus and loose connective tissue . It extends into the testis itself to line the surfaces of individual septa of testis .
The undescended testis is at increased risk of testicular torsion. [17] The mechanism for torsion in the undescended testicle is not fully understood, though it may be due to abnormal contractions of the cremaster muscle, which covers the testicle and spermatic cord and is responsible for raising and lowering the testicle to regulate scrotal ...