Search results
Results From The WOW.Com Content Network
Follicular dendritic cell sarcoma (FDCS) is an extremely rare neoplasm.While the existence of FDC tumors was predicted by Lennert in 1978, the tumor wasn't fully recognized as its own cancer until 1986 after characterization by Monda et al. [1] [2] It accounts for only 0.4% of soft tissue sarcomas, but has significant recurrent and metastatic potential and is considered an intermediate grade ...
Duodenal-type follicular lymphoma (DFL) is a form of lymphoma in which certain lymphocyte types, the B-cell-derived centrocytes and centroblasts, form lymph node follicle-like structures principally in the duodenum and other parts of the small intestine. It is an indolent disease which on rare occasions progresses to a more aggressive lymphoma ...
- Follicular dendritic cells have round nuclei, centrally located nucleoli, bland and dispersed chromatin, and flattening of adjacent nuclear membrane. Follicular dendritic cells ( FDC ) are cells of the immune system found in primary and secondary lymph follicles ( lymph nodes ) of the B cell areas of the lymphoid tissue .
In situ follicular lymphoma is an accumulation of monoclonal B cells (i.e. cells descendent from a single ancestral cell) in the germinal centers of lymphoid tissue. These cells commonly bear a pathological genomic abnormality, i.e. a translocation between position 32 on the long (i.e. "q") arm of chromosome 14 and position 21 on chromosome 18's q arm.
GC B cells that are best able to present antigen to T follicular helper cells and produce the strongest B cell receptor signal are positively selected in the light zone of the germinal center. [4] Therefore, positive selection of GC B cells in the light zone results in B cells that express antibodies with high affinity for the antigen. [3]
The means by which EBV establishes a dendritic-histiocytic cell (i.e. follicular dendritic cell) infection are unclear. Follicular dendritic cells are connective tissue rather than lymphoid cells. They do, however, have a surface membrane receptor, CD21 (also known as complement receptor type 2), which EBV uses to enter B cells. EBV may escape ...
A VIPoma or vipoma (/ v ɪ ˈ p oʊ m ə /) is a rare endocrine tumor [1] that overproduces vasoactive intestinal peptide (thus VIP + -oma). The incidence is about 1 per 10,000,000 per year. VIPomas usually (about 90%) originate from the non-β islet cells of the pancreas. They are sometimes associated with multiple endocrine neoplasia type 1.
Histology of a normal lymphoid follicle, with marginal zone annotated at bottom.. Numerous factors appear to be involved in the development of EMZL. In a small number of cases where there is a family history of a blood cancer particularly leukemia, or a number of autoimmune diseases such as Sjögren syndrome and lupus erythematosus, there is seen to be an increased frequency.