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Noise exposure is the cause of approximately half of all cases of hearing loss, causing some degree of problems in 5% of the population globally. [5] The National Institute for Occupational Safety and Health (NIOSH) recognizes that the majority of hearing loss is not due to age, but due to noise exposure.
Hearing loss may have many different causes, but among those with tinnitus, the major cause is cochlear injury. [36] In many cases no underlying cause is identified. [2] [38] Ototoxic drugs also may cause subjective tinnitus, as they may cause hearing loss, [15] or increase the damage done by exposure to loud noise. [39]
Tinnitus Retraining Therapy or TRT, Round and Oval Window Reinforcement Hyperacusis is an increased sensitivity to sound and a low tolerance for environmental noise. Definitions of hyperacusis can vary significantly; it often revolves around damage to or dysfunction of the stapes bone , stapedius muscle or tensor tympani ( eardrum ).
Tinnitus is common in the United States, affecting as many as 25% of adults, according to the National Institute on Deafness and Other Communication Disorders. Children can also develop the condition.
Though the pathophysiology of tinnitus is not known, noise exposure can be a contributing factor, therefore tinnitus can be associated with hearing loss, generated by the cochlea and central nervous system (CNS). High frequency hearing loss causes a high pitched tinnitus and low frequency hearing loss causes a roaring tinnitus. [19]
This unique chemotherapeutic agent causes oxidative damage to the nucleotides and leads to single- and double-stranded breaks in DNA. Excess breaks in DNA eventually causes cell death. [9] Few case reports have identified the development of ototoxicity in some elderly patients who were administered with bleomycin. [17]
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