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Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...
On the history of the Contergan (thalidomide) catastrophe in the light of drug legislation, Dtsch Med Wochenschr. 2001 October 19;126(42):1183-6. Shah RR., Thalidomide, drug safety and early drug regulation in the UK, Adverse Drug React Toxicol Rev. 2001 Dec;20(4):199-255.
Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. The racemization process can occur in vivo.
Spain and the United States signs the Pact of Madrid. 1955 Spain joins the United Nations. 1959: Spanish miracle: A period of economic growth began. 1973: Spanish miracle: The period ended. 1975: History of Spain (1975–present) 6 November: The Green March forced Spain to hand over its last remaining colonial possession, Spanish Sahara, to ...
Frances Kathleen Oldham Kelsey CM (née Oldham; July 24, 1914 – August 7, 2015) was a Canadian-American [1] pharmacologist and physician. As a reviewer for the U.S. Food and Drug Administration (FDA), she refused to authorize thalidomide for market because she had concerns about the lack of evidence regarding the drug's safety. [2]
The history of Spain dates to contact between the pre-Roman peoples of the Mediterranean coast of the Iberian Peninsula with the Greeks and Phoenicians. During Classical Antiquity , the peninsula was the site of multiple successive colonizations of Greeks, Carthaginians , and Romans.
1968 – After a long campaign by The Sunday Times, a compensation settlement for the UK victims of thalidomide was reached with Distillers Company (now part of Diageo), which had distributed the drug in the UK. [88] [89] This compensation, which is distributed by the Thalidomide Trust in the UK, was substantially increased by Diageo in 2005. [90]
The thalidomide molecule is a synthetic derivative of glutamic acid and consists of a glutarimide ring and a phthaloyl ring (Figure 5). [15] [16] Its IUPAC name is 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione and it has one chiral center [15] After thalidomide's selective inhibition of TNF-α had been reported, a renewed effort was put in thalidomide's clinical development.