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Antiphospholipid syndrome is known for causing arterial or venous blood clots, in any organ system, and pregnancy-related complications.While blood clots and pregnancy complications are the most common and diagnostic symptoms associated with APS, other organs and body parts may be affected like platelet levels, heart, kidneys, brain, and skin.
Catastrophic antiphospholipid syndrome (CAPS), also known as Asherson's syndrome, is a rare autoimmune disease in which widespread, intravascular clotting causes multi-organ failure. [1] The syndrome is caused by antiphospholipid antibodies that target a group of proteins in the body that are associated with phospholipids .
The main indication for testing for lupus anticoagulant is a suspected antiphospholipid syndrome, whose main manifestations are blood clots in both arteries and veins as well as pregnancy-related complications such as miscarriage, stillbirth, preterm delivery, and severe preeclampsia. [8]
Approximately 20% of people with SLE have clinically significant levels of antiphospholipid antibodies, which are associated with antiphospholipid syndrome. [135] Antiphospholipid syndrome is also related to the onset of neural lupus symptoms in the brain. In this form of the disease, the cause is very different from lupus: thromboses (blood ...
A prominent example is antiphospholipid syndrome, [1] [16] which is caused by antibodies against constituents of the cell membrane, particularly lupus anticoagulant (first found in people with the disease systemic lupus erythematosus but often detected in people without the disease), anti-cardiolipin antibodies, and anti-β 2-glycoprotein 1 ...
Back pain. When your back aches and there’s no obvious cause (like lifting heavy boxes or falling), inflammation could be the root cause. Inflammatory back pain tends to come on gradually and ...
Sometimes, because of these, patients with lupus develop an antiphospholipid syndrome, where the antiphospholipid antibodies cause a hypercoagulable state, meaning they’re more prone to developing clots and having complications like deep vein thrombosis, hepatic vein thrombosis, and stroke.
Back pain in general is a known cause of chronic pain. Both Samadani and Stanford University pain management specialist Dr. Beth Darnall say that spondylolisthesis is a common source of back pain.