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Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine hydrochloride as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications was shown in ...
In addition to other formulations, ciclopirox is used in lacquers for topical treatment of onychomycosis (fungal infections of the nails). A meta-analysis of the six trials of nail infections available in 2009 concluded that they provided evidence that topical ciclopirox had poor cure rates, and that amorolfine might be substantially more effective, but more research was required.
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These medications come as creams, gels, lotions, ointments, powders, shampoos, tinctures and sprays. Most antifungal drugs induce fungal cell death by destroying the cell wall of the fungus . These drugs inhibit the production of ergosterol , which is a fundamental component of the fungal cell membrane and wall .
[2] [5] Trimming the affected nails when on treatment also appears useful. [2] There is a ciclopirox-containing nail polish, but there is no evidence that it works. [2] The condition returns in up to half of cases following treatment. [2] Not using old shoes after treatment may decrease the risk of recurrence. [3]
The Anusol range includes creams, ointments, and suppositories. Anusol is now known under the brand name Tucks in the United States and some other areas, while being marketed under the Anusol name in other markets. The active ingredients and usage remains unchanged between these brand names.