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Alcohol and some drugs can also cause breast enlargement. [4] [7] Other causes may include Klinefelter syndrome, metabolic dysfunction, or a natural decline in testosterone production. [4] [6] [8] This may occur even if the levels of estrogens and androgens are both appropriate, but the ratio is altered. [7]
Some of its side effects, including breast pain/tenderness and gynecomastia, are far less likely to occur when the drug is combined with a GnRH analogue, [205] while certain other side effects, including hot flashes, depression, fatigue, and sexual dysfunction, [206] occur much more frequently in combination with a GnRH analogue.
Mammoplasia can be an effect or side effect of various drugs, including estrogens, [2] [13] antiandrogens such as spironolactone, [14] cyproterone acetate, [15] bicalutamide, [16] [17] and finasteride, [18] [19] growth hormone, [20] [21] and drugs that elevate prolactin levels such as D 2 receptor antagonists like antipsychotics (e.g ...
Gynecomastia can cause your nipples to become swollen or tender. You might feel an enlargement in the glandular tissue behind one or both of your nipples. ... These drugs make it easier to get and ...
Gynecomastia, or male breast enlargement (reported by 0.5 percent of men) Breast tenderness (reported by 0.4 percent of men) Like in the above trial, men placed in the control group received a non ...
CPA can sometimes cause breast changes in men including gynecomastia (breast development) and breast tenderness. [10] Rates of gynecomastia of 4 to 30% have been reported. [14] [15] [16] [9] [17] Galactorrhea (milk outflow) can also occur in men, due to the strong progestogenic effects of CPA. [10]
The drug may cause adrenal insufficiency so the level of the adrenocortical hormones should be monitored while taking it. [ 13 ] [ 36 ] Oral ketoconazole at a dosage range of 400 to 2,000 mg/day has been found to result in a rate of gynecomastia of 21%.
Because of its antiandrogenic activity, spironolactone can cause breast tenderness, gynecomastia (breast development), feminization in general, and demasculinization, as well as sexual dysfunction including loss of libido and erectile dysfunction, although these side effects are usually confined to high doses of spironolactone. [109]