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Because many bacteria metabolize glucose, and because the blood–brain barrier minimizes transversal, the ratio can be useful in determining whether there is a bacterial infection in the CSF. The normal ratio is 0.6. [1] It is used to distinguish between bacterial and viral meningitis, as it is often lowered in bacterial meningitis and normal ...
CSF vs serum c-reactive protein and procalcitonin have not been shown to elucidate whether meningitis is bacterial or viral. [ 14 ] In certain cases, a CT scan of the head should be done before a lumbar puncture such as in those with poor immune function or those with increased intracranial pressure . [ 1 ]
CSF glucose levels can be useful in distinguishing among causes of meningitis as more than 50% of patients with bacterial meningitis have decreased CSF glucose levels while patients with viral meningitis usually have normal CSF glucose levels. Decrease in glucose levels during a CNS infection is caused due to glycolysis by both white cells and ...
Reference ranges for other molecules in CSF Substance Lower limit Upper limit Unit Corresponds to % of that in plasma Glucose: 50 [2] 80 [2] mg/dL ~60% [1] 2.2, [3] 2.8 [1] 3.9, [3] 4.4 [1] mmol/L Protein: 15 [1] [2] 40, [4] 45 [1] [2] mg/dL ~1% [1] Albumin: 7.8 [5] 40 [5] mg/dL: 0 [6] - 0.7% [6] - corresponding to an albumin (CSF/serum ...
In bacterial meningitis it is typically lower; the CSF glucose level is therefore divided by the blood glucose (CSF glucose to serum glucose ratio). A ratio ≤0.4 is indicative of bacterial meningitis; [ 52 ] in the newborn, glucose levels in CSF are normally higher, and a ratio below 0.6 (60%) is therefore considered abnormal. [ 8 ]
CSF pressure, as measured by lumbar puncture, is 10–18 cmH 2 O (8–15 mmHg or 1.1–2 kPa) with the patient lying on the side and 20–30 cmH 2 O (16–24 mmHg or 2.1–3.2 kPa) with the patient sitting up. [30] In newborns, CSF pressure ranges from 8 to 10 cmH 2 O (4.4–7.3 mmHg or 0.78–0.98 kPa).
Growth indicated a bacterial meningitis, while no growth indicated another cause denoted "aseptic" meningitis. [1] The most common form of this is viral meningitis. [1] Recent medical advances allows rapid polymerase chain reaction (PCR) testing that analyzes the CSF for DNA or RNA. This can quickly determine if there are bacterial or viral ...
Aseptic meningitis is the inflammation of the meninges, a membrane covering the brain and spinal cord, in patients whose cerebral spinal fluid test result is negative with routine bacterial cultures. Aseptic meningitis is caused by viruses , mycobacteria , spirochetes , fungi , medications , and cancer malignancies. [ 1 ]